Listar por autor "Welsing, Paco M.J."

Mostrando ítems 1-9 de 9

    • Baseline clinical characteristics of predicted structural and pain progressors in the IMI-APPROACH knee OA cohort 

      van Helvoort, Eefje M.; Ladel, Christoph H.; Mastbergen, Simon; Kloppenburg, Margreet; Blanco García, Francisco J; Haugen, Ida K.; Berenbaum, Francis; Bacardit, Jaume; Widera, Pawel; Welsing, Paco M.J.; Lafeber, Floris (BMJ, 2021-08-23)
      [Abstract] Objectives: To describe the relations between baseline clinical characteristics of the Applied Public-Private Research enabling OsteoArthritis Clinical Headway (IMI-APPROACH) participants and their predicted ...

    • Cohort profile: the Applied Public-Private Research enabling OsteoArthritis Clinical Headway (IMI-APPROACH) study: a 2-year, European, cohort study to describe, validate and predict phenotypes of osteoarthritis using clinical, imaging and biochemical markers 

      van Helvoort, Eefje M.; van Spil, Willem E.; Jansen, Mylène P.; Welsing, Paco M.J.; Kloppenburg, Margreet; Loef, Marieke; Blanco García, Francisco J; Haugen, Ida K.; Berenbaum, Francis; Bacardit, Jaume; Ladel, Christoph H.; Loughlin, John; Bay-Jensen, Anne C.; Mobasheri, Ali; Larkin, Jonathan; Boere, Janneke; Weinans, Harrie H.; Lalande, Agnes; Marijnissen, Anne C.A.; Lafeber, Floris (BMJ, 2020-07-28)
      [Abstract] Purpose The Applied Public-Private Research enabling OsteoArthritis Clinical Headway (APPROACH) consortium intends to prospectively describe in detail, preselected patients with knee osteoarthritis (OA), using ...

    • Development and validation of a machine learning-supported strategy of patient selection for osteoarthritis clinical trials: the IMI-APPROACH study 

      Widera, Pawel; Welsing, Paco M.J.; Danso, Samuel O.; Peelen, Sjaak; Kloppenburg, Margreet; Loef, Marieke; Marijnissen, Anne C.; van Helvoort, Eefje M.; Blanco García, Francico J; Magalhaes, Joana; Berenbaum, Francis; Haugen, Ida K.; Bay-Jensen, Anne-C.; Mobasheri, Ali; Ladel, Christoph; Loughlin, John; Lafeber, Floris P.J.G.; Lalande, Agnes; Larkin, Jonathan; Weinans, Harrie; Bacardit, Jaume (Elsevier, 2023-12)
      [Abstract] Objectives. To efficiently assess the disease-modifying potential of new osteoarthritis treatments, clinical trials need progression-enriched patient populations. To assess whether the application of machine ...

    • Exploring the differences between radiographic joint space width and MRI cartilage thickness changes using data from the IMI-APPROACH cohort 

      Jansen, Mylène P.; Roemer, Frank W.; Marijnissen, Anne C.A.; Kloppenburg, Margreet; Blanco García, Francico J; Haugen, Ida K.; Berenbaum, Francis; Lafeber, Floris P.J.G.; Welsing, Paco M.J.; Mastbergen, Simon C.; Wirth, Wolfgang (Springer, 2023-01-06)
      [Abstract] Objective: Longitudinal weight-bearing radiographic joint space width (JSW) and non-weight-bearing MRI-based cartilage thickness changes often show weak correlations. The current objective was to investigate ...

    • GaitSmart Motion Analysis Compared to Commonly Used Function Outcome Measures in the IMI-APPROACH Knee Osteoarthritis Cohort 

      van Helvoort, Eefje M.; Hodgings, Diana; Mastbergen, Simon; Marijnissen, Anne C.A.; Kloppenburg, Margreet; Blanco García, Francisco J; Haugen, Ida K.; Berenbaum, Francis; Lafeber, Floris P.J.G.; Welsing, Paco M.J. (PLoS ONE, 2022-03-23)
      [Abstract] Background: There are multiple measures for assessment of physical function in knee osteoarthritis (OA), but each has its strengths and limitations. The GaitSmart® system, which uses inertial measurement units ...

    • Machine-learning predicted and actual 2-year structural progression in the IMI-APPROACH cohort 

      Jansen, Mylène P.; Wirth, Wolfgang; Bacardit, Jaume; van Helvoort, Eefje M.; Marijnissen, Anne C.A.; Kloppenburg, Margreet; Blanco García, Francico J; Haugen, Ida K.; Berenbaum, Francis; Ladel, Christoph H.; Loef, Marieke; Lafeber, Floris P.J.G.; Welsing, Paco M.J.; Mastbergen, Simon C.; Roemer, Frank W. (AME, 2023-05)
      [Abstract] In the Innovative Medicine’s Initiative Applied Public-Private Research enabling OsteoArthritis Clinical Headway (IMI-APPROACH) knee osteoarthritis (OA) study, machine learning models were trained to predict the ...

    • Neuropathic Pain in the IMI-APPROACH Knee Osteoarthritis Cohort: Prevalence and Phenotyping 

      van Helvoort, Eefje M.; Welsing, Paco M.J.; Jansen, Mylène P.; Gielis, Willem Paul; Loef, Marieke; Kloppenburg, Margreet; Blanco García, Francisco J; Haugen, Ida K.; Berenbaum, Francis; Bay-Jensen, Anne-C; Ladel, Christoph H.; Lalande, Agnes; Larkin, Jonathan; Loughlin, John; Mobasheri, Ali; Weinans, Harrie; Lafeber, Floris; Eijkelkamp, Niels; Mastbergen, Simon (BMJ, 2021-12-15)
      [Abstract] Objectives: Osteoarthritis (OA) patients with a neuropathic pain (NP) component may represent a specific phenotype. This study compares joint damage, pain and functional disability between knee OA patients with ...

    • Predicted and actual 2-year structural and pain progression in the IMI-APPROACH knee osteoarthritis cohort 

      van Helvoort, Eefje M.; Jansen, Mylène P.; Marijnissen, Anne C.A.; Kloppenburg, Margreet; Blanco García, Francisco J; Haugen, Ida K.; Berenbaum, Francis; Bay-Jensen, Anne-C.; Ladel, Christoph; Lalande, Agnes; Larkin, Jonathan; Loughlin, John; Mobasheri, Ali; Weinans, Harrie; Widera, Pawel; Bacardit, Jaume; Welsing, Paco M.J.; Lafeber, Floris P.J.G. (Oxford Academic, 2023-01)
      [Abstract] Objectives: The IMI-APPROACH knee osteoarthritis study used machine learning (ML) to predict structural and/or pain progression, expressed by a structural (S) and pain (P) predicted-progression score, to select ...

    • Relationship Between Motion, Using the GaitSmartTM System, and Radiographic Knee Osteoarthritis: An Explorative Analysis in the IMI-APPROACH Cohort 

      van Helvoort, Eefje M.; Hodgins, Diana; Mastbergen, Simon C.; Marijnissen, Anne Karien; Guehring, Hans; Loef, Marieke; Kloppenburg, Margreet; Blanco García, Francisco J; Haugen, Ida K.; Berenbaum, Francis; Lafeber, Floris; Welsing, Paco M.J. (Oxford, 2020-12-25)
      [Abstract] Objectives: To assess underlying domains measured by GaitSmartTMparameters and whether these are additional to established OA markers including patient reported outcome measures (PROMs) and radiographic parameters, ...